C-type lectin-like receptors

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August undefined, 2024

WebApr 12, 2013 · These CTLRs possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. WebC-type lectin receptors are a family of transmembrane and soluble receptors that bind carbohydrates. They trigger multiple intracellular signaling pathways leading to nuclear …

NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle ...

WebDec 18, 2012 · C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore determined the mRNA expression levels of Dectin-1, MR1, MR2, DC-SIGN, Syk, Card-9, … WebFeb 2, 2024 · Blockade of the lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) could be an attractive mechanism for lowering inflammatory and lipid risk in patients with atherosclerosis. 8 LOX‐1 is found on many of the cells associated with proatherogenic processes, such as endothelial and smooth muscle cells, macrophages ... ipf s631

C-type lectin-like receptors of the dectin-1 cluster: ligands and ...

WebApr 10, 2013 · C-type lectins (CTLs) were originally defined as a family of soluble and transmembrane receptors that bound carbohydrates via a carbohydrate recognition … WebThere are four classes of pattern-recognition receptors: toll-like receptors (TLRs), C-type lectin receptors (CLRs), nucleotide-binding oligomerization domain (NOD) leucine-rich-repeat... WebIn summary, this is the first report demonstrating synergistic collaboration between NOD1/2 and C-type lectin receptors both in vitro and in vivo. However, further studies are required to elucidate the beneficial effects of NOD-like and C-type lectin receptor collaboration during infection. ipf s9m31

Signalling through C-type lectin receptors: shaping immune

The Dectin-2 family of C-type lectin-like receptors: an update

WebDec 29, 2024 · The natural killer group 2 member D (NKG2D) receptor is a C-type lectin-like activating receptor mainly expressed by cytotoxic immune cells including NK, CD8 + T, γδ T and NKT cells and in some pathological conditions by a subset of CD4 + T cells. It binds a variety of ligands (NKG2DL) whose expressions is finely regulated by stress … WebSome of C-type lectin-like molecules possess activating/inhibitory signalling motifs that trigger downstream signalling events, suggesting the role for these receptors as positive/negative regulators of granulocyte and monocyte functions. ipf s-9681WebPlant lectin or lectin-like domains are usually involved in the perception of carbohydrates and glycans . Among them, LysM RLKs or RLPs are well studied, while C-type lectins are rare in plants. There are 42–45 L-type lectin RLKs and six L-type lectin RLPs in Arabidopsis [22–24]. ipf s-9682

"WebOct 3, 2024 · C-type lectin receptors (CLRs) play essential roles in immunity and homeostasis 1. Comprising a family of more than 1000 proteins that each contain at least one C-type lectin-like domain, CLRs have been placed into 17 groups based on their structure and/or function. " - C-type lectin-like receptors

C-type lectin-like receptors

C-type lectins in immunity and homeostasis - Nature

WebC-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an … WebJul 22, 2024 · Various PRRs have been identified in mammals, including transmembrane Toll-like receptors (TLRs), C-type lectin receptors (CLRs), cytosolic nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), and retinoic acid-inducible gene (RIG)-I-like receptors (RLRs). 1 There has been enormous progress over the past two …

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WebDectin-2 is a C-type lectin-like receptor that is expressed in myeloid cells and it is mainly expressed on DCs, monocytes and macrophages. Unlike Dectin-1, which recognizes β-glucans, Dectin-2 is a PRR that binds mannose and its CRD contains a glutamic acid-proline-asparagine (EPN) motif, which is Ca 2+-dependent. Unlike Dectin-1, which ... WebSoluble C-type lectin-like receptor 2 (sCLEC-2) has been introduced as a new biomarker of platelet activation . Elevated plasma levels of sCLEC-2 have been reported in patients with thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC) [ 16 , 17 ], as well as in patients with acute coronary syndrome [ 18 ] or acute ...

WebJun 22, 2024 · PRRs such as Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nucleotide-binding Oligomerization Domain (NOD)-like receptors (NLRs) have been widely studied in antimicrobial immunity and homeostasis. ... Dectin-1 is a glycosylated transmembrane receptor possessing an extracellular C-type lectin-like domain (CRD) … WebRecognition of the fungal cell wall by C‐type lectin receptors (CLR) initiates the antifungal immune response. Top: Simplified representation of the fungal cell wall of the three main fungal pathogens, adapted from Reference [].The cell wall of Candida albicans (yeast form, left) is composed of chitin, β‐glucans, proteins and mannans. Resting spores of …

WebApr 4, 2011 · Murine OCIL (mOCIL) is a 207 amino acid type II membrane-bound C-type lectin-like NK receptor belonging to a family of osteoclast formation inhibitors (Fig. 1 F) . Other members of this family include OCILrP1, OCILrP2 and OCILrP2b and like OCIL are encoded by genes within the murine NKC on chromosome 6 (Fig. 1). These C ... Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein. This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV). Most recently, three further subgroups were added (XV to XVII). CLECs include:

WebKey PointsCLEC-1 is restricted to CD16− myeloid DCs in human blood and acts as an inhibitory receptor to restrain downstream Th17 activation. CLEC-1–deficient rats …

WebThe C-type lectin superfamily in the immune system Protein-carbohydrate interactions serve multiple functions in the immune system. Many animal lectins (sugar-binding proteins) mediate both pathogen recognition and cell-cell interactions using structurally related Ca(2+)-dependent carbohydrate-recognition domains (C-type CRDs). ipfs algorithm of round robinWebNKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin-like receptors. [3] NKG2D is encoded by KLRK1 (killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice [4] and chromosome 12 in humans. [5] ipf s9682WebC-type lectin-like receptor carbohydrate recognition domain ITAM ITIM pattern recognition receptor Fingerprint Dive into the research topics of 'The Dectin-2 family of C-type lectin-like receptors: an update'. Together they form a unique fingerprint. C-Type Lectins Medicine & Life Sciences Dendritic Cells Medicine & Life Sciences ipf registryWebFeb 1, 2002 · In addition, C-type-lectin-like receptors have now been characterized 8, and these consist of a CRD-like domain that might bind protein or lipids, rather than … ipfs androidWebJan 17, 2024 · C-type lectin receptors (CLRs) This event has been computationally inferred from an event that has been demonstrated in another species. The inference is … ipfs adoptionWebC-type lectin receptors CLRs are a large family of transmembrane C-type lectin proteins which share a carbohydrate recognition domain, allowing the calcium-dependent … ipfs and nftWebMay 10, 2024 · The C-Type Lectin Receptor Family and Its Subtype. Lectins can selectively bind to specific carbohydrate structures, which are extremely useful tools for understanding the information encoded in carbohydrates, studying the characterization of polysaccharides and glycoproteins, recognizing cell-molecule and cell-cell interactions, … ipfs and done