WebPhase 1/2 study of DFP‐10917 administered by continuous intravenous infusion in patients with recurrent or refractory acute myeloid leukemia (PDF) Phase 1/2 study of DFP‐10917 administered by continuous intravenous infusion in patients with recurrent or refractory acute myeloid leukemia Kenzo Iizuka - Academia.edu WebMay 20, 2015 · 7077 Background: DFP-10917 has a unique mechanism of action upon prolonged administration at a low dose. Under such administration, DFP-10917 is converted to its nucleotide form and then incorporated into DNA in tumors to cause DNA strand breaks resulting in G2/M phase-arrest by cell-checkpoint regulators and ultimately the apoptosis …

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WebTo determine the MTD, RP2D and DLTs of DFP-10917 administered by 7 or 14 day continuous infusion (CI) in patients with relapsed or refractory acute leukemia. Primary … WebJan 22, 2024 · DFP-10917 as a 14-day continuous intravenous infusion at a dose of 6 mg/m 2 /day can be administered safely and appears to be effective in patients with recurrent … iowa stablemate portable stand

Phase II study of DFP-10917, a deoxycytidine analog, given by 14 …

WebDFP-10917is a novel deoxycytidine analog, CNDAC (2’-C-cyano-2’-deoxy- 1-β-D-arabino-pentofuranosyl- cytosine), that induces DNA damage in a manner unique from structurally related nucleoside analogs (cytrarabine, decitabine, gemcitabine). Following tri-phosphorylation of 5’-OH in the tumor cell, tri-phosphorylated WebDörentrup was founded in 1901 and was one of the pioneers in the manufacturing of refractory products for the foundry industry in Germany. Our company philosophy, … WebDec 2, 2016 · DFP-10917 is a nucleoside analog similar to cytarabine with a unique mechanism of action when administered at a low dose. Upon prolonged administration, DFP-10917 is converted to its nucleotide form and incorporated into tumor DNA, causing DNA strand breaks. open file in append mode in python