WebFeb 24, 2011 · KLF3 is a member of the Krüppel-like factor (KLF) family of transcription factors. These proteins are classified by the presence of three C-terminal C2H2 zinc … WebNov 27, 2024 · To further investigate the effects of KLF8 on VEGFA expression, pcDNA3.1-KLF8 was constructed to up-regulate KLF8 expression, and pcDNA3.1-KLF8 or pcDNA3.1 was transfected into SMMC7721 cells.
Krüppel-like factors in glycolipid metabolic diseases
WebMay 18, 2024 · PPARγ is a member of the nuclear receptor superfamily, which is mainly expressed in adipose tissue and plays an important role in regulating glycolipid metabolism, insulin sensitivity, and inflammation. KLF8 and KLF9 are involved in adipocyte differentiation by transactivating PPARγ2 [6, 7], but the overexpression of KLF8 has the opposite ... WebJun 20, 2015 · In addition, the expression of KLF8 was highly elevated in the contractile phenotype of VSMC compared with the synthetic phenotype, and forced expression of KLF8 in the synthetic phenotype of... h.c. wilcox fabrications ltd
The Role of Telocytes and Telocyte-Derived Exosomes in the …
WebMay 20, 2024 · Knockout of both Klf3 and Klf8 resulted in embryonic lethality, suggesting genetic interaction between the 2 genes. RT-PCR analysis showed that Klf8 expression was upregulated in Klf3 -/- erythroid tissues. Microarray assays revealed that fetal liver of Klf3 -/- Klf8 -/- embryos exhibited greater dysregulation of gene expression than either ... WebJan 1, 2024 · Regulation of vascular smooth muscle cell (VSMC) phenotype plays an essential role in many cardiovascular diseases. In the present study, we provide evidence that krüppel-like factor 8 (KLF8) is essential for tumor necrosis factor α (TNFα)-induced phenotypic conversion of VSMC obtained from thoracic aorta from 4-week-old SD rats. WebApr 14, 2024 · Comprehensive maps of chromatin contacts in fetal and adult cattle muscle. To construct and compare chromatin structures between fetal and adult stages, we determined genome-wide chromatin interaction frequency by carrying out the Hi-C experiments in Longissimus dorsi muscle. Four individuals with two biological replicates … golden cheese company of california